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Title:

Stromal heterogeneity in pancreatic cancer and chronic pancreatitis.

Document type:
Journal Article
Author(s):
Haeberle, Lena; Steiger, Katja; Schlitter, Anna Melissa; Safi, Sami Alexander; Knoefel, Wolfram Trudo; Erkan, Mert; Esposito, Irene
Abstract:
BACKGROUND/OBJECTIVES: An abundant stromal reaction is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). The cells mainly responsible for the stromal reaction are activated pancreatic stellate cells (PSCs). Despite their crucial role, PSCs are not well characterized. PSCs share characteristics with the better-known hepatic stellate cells (HSCs). The aim of this study was a detailed analysis of PSCs in PDAC and CP. METHODS: Whole-slide specimens of CP (n = 12) a...     »
Journal title abbreviation:
Pancreatology
Year:
2018
Journal volume:
18
Journal issue:
5
Pages contribution:
536-549
Language:
eng
Fulltext / DOI:
doi:10.1016/j.pan.2018.05.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29778400
Print-ISSN:
1424-3903
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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