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Titel:

Validation of a Targeted Next-Generation Sequencing Panel for Tumor Mutation Burden Analysis: Results from the Onconetwork Immuno-Oncology Consortium.

Dokumenttyp:
Journal Article
Autor(en):
Fenizia, Francesca; Alborelli, Ilaria; Costa, Jose Luis; Vollbrecht, Claudia; Bellosillo, Beatriz; Dinjens, Winand; Endris, Volker; Heydt, Carina; Leonards, Katharina; Merkelback-Bruse, Sabine; Pfarr, Nicole; van Marion, Ronald; Allen, Christopher; Chaudhary, Ruchi; Gottimukkala, Rajesh; Hyland, Fiona; Wong-Ho, Elaine; Jermann, Philip; Machado, Jose Carlos; Hummel, Michael; Stenzinger, Albrecht; Normanno, Nicola
Abstract:
Tumor mutation burden (TMB) is evaluated as a biomarker of response to immunotherapy. We present the efforts of the Onconetwork Immuno-Oncology Consortium to validate a commercial targeted sequencing test for TMB calculation. A three-phase study was designed to validate the Oncomine Tumor Mutational Load (OTML) assay at nine European laboratories. Phase 1 evaluated reproducibility and accuracy on seven control samples. In phase 2, six formalin-fixed, paraffin-embedded samples tested with Foundat...     »
Zeitschriftentitel:
J Mol Diagn
Jahr:
2021
Band / Volume:
23
Heft / Issue:
7
Seitenangaben Beitrag:
882-893
Volltext / DOI:
doi:10.1016/j.jmoldx.2021.04.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33964449
Print-ISSN:
1525-1578
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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