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Titel:

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia.

Dokumenttyp:
Journal Article
Autor(en):
Alankus, Begüm; Ecker, Veronika; Vahl, Nathalie; Braun, Martina; Weichert, Wilko; Macher-Göppinger, Stephan; Gehring, Torben; Neumayer, Tanja; Zenz, Thorsten; Buchner, Maike; Ruland, Jürgen
Abstract:
Clinical evidence suggests alterations in receptor activator of NF-κB (RANK) signaling are key contributors to B cell autoimmunity and malignancy, but the pathophysiological consequences of aberrant B cell-intrinsic RANK signaling remain unknown. We generated mice that express a human lymphoma-derived, hyperactive RANKK240E variant in B lymphocytes in vivo. Forced RANK signaling disrupted B cell tolerance and induced a fully penetrant systemic lupus erythematosus-like disease in addition to the...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2021
Band / Volume:
218
Heft / Issue:
2
Volltext / DOI:
doi:10.1084/jem.20200517
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33075129
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie
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