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Title:

Caspase-8 modulates physiological and pathological angiogenesis during retina development.

Document type:
Journal Article
Author(s):
Tisch, Nathalie; Freire-Valls, Aida; Yerbes, Rosario; Paredes, Isidora; La Porta, Silvia; Wang, Xiaohong; Martín-Pérez, Rosa; Castro, Laura; Wong, Wendy Wei-Lynn; Coultas, Leigh; Strilic, Boris; Gröne, Hermann-Josef; Hielscher, Thomas; Mogler, Carolin; Adams, Ralf H; Heiduschka, Peter; Claesson-Welsh, Lena; Mazzone, Massimiliano; López-Rivas, Abelardo; Schmidt, Thomas; Augustin, Hellmut G; Ruiz de Almodovar, Carmen
Abstract:
During developmental angiogenesis, blood vessels grow and remodel to ultimately build a hierarchical vascular network. Whether, how, cell death signaling molecules contribute to blood vessel formation is still not well understood. Caspase-8 (Casp-8), a key protease in the extrinsic cell death-signaling pathway, regulates cell death via both apoptosis and necroptosis. Here, we show that expression of Casp-8 in endothelial cells (ECs) is required for proper postnatal retina angiogenesis. EC-specif...     »
Journal title abbreviation:
J Clin Invest
Year:
2019
Journal volume:
129
Journal issue:
12
Pages contribution:
5092-5107
Fulltext / DOI:
doi:10.1172/JCI122767
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31454332
Print-ISSN:
0021-9738
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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