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Title:

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Heil, Joschka; Olsavszky, Victor; Busch, Katrin; Klapproth, Kay; de la Torre, Carolina; Sticht, Carsten; Sandorski, Kajetan; Hoffmann, Johannes; Schönhaber, Hiltrud; Zierow, Johanna; Winkler, Manuel; Schmid, Christian David; Staniczek, Theresa; Daniels, Deborah E; Frayne, Jan; Metzgeroth, Georgia; Nowak, Daniel; Schneider, Sven; Neumaier, Michael; Weyer, Vanessa; Groden, Christoph; Gröne, Hermann-Josef; Richter, Karsten; Mogler, Carolin; Taketo, Makoto Mark; Schledzewski, Kai; Géraud, Cyrill; Go...     »
Abstract:
Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we show that BM sinusoidal EC (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC (Ctnnb1OE-SEC) generated by using a BM-SEC-restricted Cre mouse line (Stab2-iCreF3) develop fatal anemia. While activation of Wnt-signaling in BM-SEC causes an increase in erythroblast subsets (PII-PIV), matu...     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-27161-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34845225
Print-ISSN:
2041-1723
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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