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Title:

A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma.

Document type:
Journal Article
Author(s):
Wagner, Ferdinand; Holzapfel, Boris M; Martine, Laure; McGovern, Jacqui; Lahr, Christoph A; Boxberg, Melanie; Prodinger, Peter M; Grässel, Susanne; Loessner, Daniela; Hutmacher, Dietmar W
Abstract:
The quest for predictive tumor markers for osteosarcoma (OS) has not well progressed over the last two decades due to a lack of preclinical models. The aim of this study was to investigate if microenvironmental modifications in an original humanized in vivo model alter the expression of OS tumor markers. Human bone micro-chips and bone marrow, harvested during hip arthroplasty, were implanted at the flanks of NOD/scid mice. We administered recombinant human bone morphogenetic protein 7 (rhBMP-7)...     »
Journal title abbreviation:
Acta Biomater
Year:
2019
Journal volume:
89
Pages contribution:
372-381
Language:
eng
Fulltext / DOI:
doi:10.1016/j.actbio.2019.02.051
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30836200
Print-ISSN:
1742-7061
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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