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Title:

Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy.

Document type:
Journal Article
Author(s):
Schulze, Sarah; Stöß, Christian; Lu, Miao; Wang, Baocai; Laschinger, Melanie; Steiger, Katja; Altmayr, Felicitas; Friess, Helmut; Hartmann, Daniel; Holzmann, Bernhard; Hüser, Norbert
Abstract:
Stimulation of cytosolic nucleic acid sensors of innate immunity by pathogen-derived nucleic acids is important for antimicrobial defence, but stimulation through self-derived nucleic acids may contribute to autoinflammation and cancer. DNA sensing in the cytosol requires the stimulator of interferon genes (STING), while cytosolic RNA sensors use mitochondrial antiviral-signalling protein (MAVS). In a murine model of two-thirds hepatectomy, combined deficiency of MAVS and STING resulted in stron...     »
Journal title abbreviation:
Sci Rep
Year:
2018
Journal volume:
8
Journal issue:
1
Pages contribution:
12271
Language:
eng
Fulltext / DOI:
doi:10.1038/s41598-018-29924-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30115978
Print-ISSN:
2045-2322
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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