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Document type:
Journal Article; Multicenter Study; Validation Studies; Article
Author(s):
Hirsch, B; Endris, V; Lassmann, S; Weichert, W; Pfarr, N; Schirmacher, P; Kovaleva, V; Werner, M; Bonzheim, I; Fend, F; Sperveslage, J; Kaulich, K; Zacher, A; Reifenberger, G; Köhrer, K; Stepanow, S; Lerke, S; Mayr, T; Aust, D E; Baretton, G; Weidner, S; Jung, A; Kirchner, T; Hansmann, M L; Burbat, L; von der Wall, E; Dietel, M; Hummel, M
Title:
Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics.
Abstract:
The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based targeted next-generation sequencing (NGS). However, only few studies are available comparing multicenter testing of different NGS platforms and gene panels. Therefore, seven partner sites of the German Cancer Consortium (DKTK) performed a multicenter interlaboratory trial for targeted NGS using the same formalin-fixed, paraffin-embedded (FF...     »
Journal title abbreviation:
Virchows Arch
Year:
2018
Journal volume:
472
Journal issue:
4
Pages contribution:
557-565
Language:
eng
Fulltext / DOI:
doi:10.1007/s00428-017-2288-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29374318
Print-ISSN:
0945-6317
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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