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Title:

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease.

Document type:
Journal Article
Author(s):
Höfling, Corinna; Shehabi, Emira; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F; Hartlage-Rübsamen, Maike; Roßner, Steffen
Abstract:
Amyloid precursor protein (APP) transgenic animal models of Alzheimer's disease have become versatile tools for basic and translational research. However, there is great heterogeneity of histological, biochemical, and functional data between transgenic mouse lines, which might be due to different transgene expression patterns. Here, the expression of human APP (hAPP) by GABAergic hippocampal interneurons immunoreactive for the calcium binding proteins parvalbumin, calbindin, calretinin, and for...     »
Journal title abbreviation:
Front Neurosci
Year:
2019
Journal volume:
13
Pages contribution:
137
Language:
eng
Fulltext / DOI:
doi:10.3389/fnins.2019.00137
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30853883
Print-ISSN:
1662-4548
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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