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Title:

Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.

Document type:
Journal Article
Author(s):
Regel, Ivonne; Raulefs, Susanne; Benitz, Simone; Mihaljevic, Charlotte; Rieder, Simon; Leinenkugel, Georg; Steiger, Katja; Schlitter, Anna Melissa; Esposito, Irene; Mayerle, Julia; Kong, Bo; Kleeff, Jörg; Michalski, Christoph W
Abstract:
Acute pancreatitis is accompanied by acinar cell damage releasing potential toll-like receptor 3 (TLR3) ligands. So far, TLR3 is known as a pattern recognition receptor in the immune signaling cascade triggering a type I interferon response. In addition, TLR3 signaling contributes to programmed cell death through the activation of caspase 8. However, the functional role of TLR3 and its downstream toll-like receptor adaptor molecule 1 (TICAM1) in the inflamed pancreas is unknown.To uncover the ro...     »
Journal title abbreviation:
Pancreatology
Year:
2019
Journal volume:
19
Journal issue:
1
Pages contribution:
149-157
Language:
eng
Fulltext / DOI:
doi:10.1016/j.pan.2018.12.005
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30583980
Print-ISSN:
1424-3903
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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