Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer.

Dokumenttyp:
Journal Article
Autor(en):
Schug, Christina; Urnauer, Sarah; Jäckel, Carsten; Schmohl, Kathrin Alexandra; Tutter, Mariella; Steiger, Katja; Schwenk, Nathalie; Schwaiger, Markus; Wagner, Ernst; Nelson, Peter Jon; Spitzweg, Christine
Abstract:
Based on their excellent tumor-homing capacity, genetically engineered mesenchymal stem cells (MSCs) are under investigation as tumor-selective gene delivery vehicles. Transgenic expression of the sodium iodide symporter (NIS) in genetically engineered MSCs allows noninvasive tracking of MSC homing by imaging of functional NIS expression as well as therapeutic application of 131I. The use of tumor stroma-activated promoters can improve tumor-specific MSC-mediated transgene delivery. The essentia...     »
Zeitschriftentitel:
Endocr Relat Cancer
Jahr:
2019
Band / Volume:
26
Heft / Issue:
1
Seitenangaben Beitrag:
89-101
Sprache:
eng
Volltext / DOI:
doi:10.1530/ERC-18-0173
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30121623
Print-ISSN:
1351-0088
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
 BibTeX