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Titel:

Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance.

Dokumenttyp:
Journal Article
Autor(en):
Duernberger, Yvonne; Liu, Shu; Riemschoss, Katrin; Paulsen, Lydia; Bester, Romina; Kuhn, Peer-Hendrik; Schölling, Manuel; Lichtenthaler, Stefan F; Vorberg, Ina
Abstract:
Prions of lower eukaryotes are transmissible protein particles that propagate by converting homotypic soluble proteins into growing protein assemblies. Prion activity is conferred by so-called prion domains, regions of low complexity that are often enriched in glutamines and asparagines (Q/N). The compositional similarity of fungal prion domains with intrinsically disordered domains found in many mammalian proteins raises the question of whether similar sequence elements can drive prion-like phe...     »
Zeitschriftentitel:
Mol Cell Biol
Jahr:
2018
Band / Volume:
38
Heft / Issue:
15
Sprache:
eng
Volltext / DOI:
doi:10.1128/MCB.00111-18
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29784771
Print-ISSN:
0270-7306
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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