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Document type:
journal article 
Author(s):
Schlott, Fabian; Steubl, Dominik; Ameres, Stefanie; Moosmann, Andreas; Dreher, Stefan; Heemann, Uwe; Hösel, Volker; Busch, Dirk H; Neuenhahn, Michael 
Title:
Characterization and clinical enrichment of HLA-C*07:02-restricted Cytomegalovirus-specific CD8+ T cells. 
Abstract:
Human Cytomegalovirus (CMV) reactivation remains a major source of morbidity in patients after solid organ and hematopoietic stem cell transplantation (HSCT). Adoptive T cell therapy (ACT) with CMV-specific T cells is a promising therapeutic approach for HSCT recipients, but might be counteracted by CMV's immune evasion strategies. HLA-C*07:02 is less susceptible to viral immune evasion suggesting HLA-C*07:02-restricted viral epitopes as promising targets for ACT. For a better understanding of H...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2018 
Journal volume:
13 
Journal issue:
Pages contribution:
e0193554 
Language:
eng 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene