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Document type:
journal article 
Author(s):
Schmidt, Marcel Oliver; Garman, Khalid Ammar; Lee, Yong Gu; Zuo, Chong; Beck, Patrick James; Tan, Mingjun; Aguilar-Pimentel, Juan Antonio; Ollert, Markus; Schmidt-Weber, Carsten; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabe de Angelis, Martin; German Mouse Clinic Consortium; Tassi, Elena; Riegel, Anna Tate; Wellstein, Anton; Becker, Lore; Vernaleken, Alexandra; Klopstock, Thomas; Adler, Thure; Treise, Irina; Horsch, Marion; Moreth, Kristin; Brommage, Robert; Hans, Wolfgang; Östereicher, Manuela;...    »
 
Title:
The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation. 
Abstract:
Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in various cancers. Here we evaluated the contribution of endogenous FGFBP1 to a wide range of organ functions as well as to skin pathologies using Fgfbp1-knockout mice. Relative to wild-type littermates, k...    »
 
Journal title abbreviation:
J Invest Dermatol 
Year:
2018 
Journal volume:
138 
Journal issue:
Pages contribution:
179-188 
Language:
eng 
Print-ISSN:
0022-202X 
TUM Institution:
Institut für Molekulare Allergologie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene