Benutzer: Gast  Login
Titel:

Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens.

Dokumenttyp:
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Neudorfer, J; Schmidt, B; Huster, KM; Anderl, F; Schiemann, M; Holzapfel, G; Schmidt, T; Germeroth, L; Wagner, H; Peschel, C; Busch, DH; Bernhard, H
Abstract:
The development of MHC/peptide multimers has facilitated the visualization and purification of antigen-specific T cells. However, the persistence of multimers leads to prolonged T cell receptor signaling and subsequently to altered T-cell function. We have recently developed a new type of MHC/peptide multimers, which can be dissociated from the T cell. Herein, we have generated and tested for the first time reversible HLA/peptide multimers, termed Streptamers, for the isolation of human T cells....     »
Zeitschriftentitel:
J Immunol Methods
Jahr:
2007
Band / Volume:
320
Heft / Issue:
1-2
Seitenangaben Beitrag:
119-31
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jim.2007.01.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17306825
Print-ISSN:
0022-1759
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX