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Titel:

Cysteine Residues in Helicobacter pylori Adhesin HopQ are Required for CEACAM-HopQ Interaction and Subsequent CagA Translocation.

Dokumenttyp:
Journal Article
Autor(en):
Hamway, Youssef; Taxauer, Karin; Moonens, Kristof; Neumeyer, Victoria; Fischer, Wolfgang; Schmitt, Verena; Singer, Bernhard B; Remaut, Han; Gerhard, Markus; Mejías-Luque, Raquel
Abstract:
Attachment to the host gastric mucosa is a key step in Helicobacter pylori infection. Recently, a novel adhesin, HopQ, was shown to bind distinct host CEACAM proteins-an interaction that was found to be essential for the translocation of CagA, a key virulence factor of H. pylori. The HopQ-CEACAM1 co-crystal structure revealed a binding mode dependent on loops in HopQ that are clasped by disulfide bonds. In this study, we investigated the importance of these cysteine residues for CEACAM1 engageme...     »
Zeitschriftentitel:
Microorganisms
Jahr:
2020
Band / Volume:
8
Heft / Issue:
4
Volltext / DOI:
doi:10.3390/microorganisms8040465
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32218315
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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