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Title:

TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kälin, Roland E; Cai, Linzhi; Li, Yuping; Zhao, Dongxu; Zhang, Huabin; Cheng, Jiying; Zhang, Wenlong; Wu, Yingxi; Eisenhut, Katharina; Janssen, Philipp; Schmitt, Lukas; Enard, Wolfgang; Michels, Friederike; Flüh, Charlotte; Hou, Mengzhuo; Kirchleitner, Sabrina V; Siller, Sebastian; Schiemann, Matthias; Andrä, Immanuel; Montanez, Eloi; Giachino, Claudio; Taylor, Verdon; Synowitz, Michael; Tonn, Jörg-Christian; von Baumgarten, Louisa; Schulz, Christian; Hellmann, Ines; Glass, Rainer
Abstract:
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP)...     »
Journal title abbreviation:
Cell Syst
Year:
2021
Journal volume:
12
Journal issue:
3
Pages contribution:
248-262.e7
Fulltext / DOI:
doi:10.1016/j.cels.2021.01.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33592194
Print-ISSN:
2405-4712
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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