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Title:

Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse Model.

Document type:
Journal Article
Author(s):
Festag, Marvin M; Festag, Julia; Fräßle, Simon P; Asen, Theresa; Sacherl, Julia; Schreiber, Sophia; Mück-Häusl, Martin A; Busch, Dirk H; Wisskirchen, Karin; Protzer, Ulrike
Abstract:
Chimeric antigen receptor (CAR) T cell therapy is a promising novel therapeutic approach for cancer but also for chronic infection. We have developed a fully human, second-generation CAR directed against the envelope protein of hepatitis B virus on the surface of infected cells (S-CAR). The S-CAR contains a human B cell-derived single-chain antibody fragment and human immunoglobulin G (IgG) spacer, CD28- and CD3-signaling domains that may be immunogenic in mice. Because immunosuppression will wo...     »
Journal title abbreviation:
Mol Ther
Year:
2019
Journal volume:
27
Journal issue:
5
Pages contribution:
947-959
Fulltext / DOI:
doi:10.1016/j.ymthe.2019.02.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30852138
Print-ISSN:
1525-0016
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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