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Title:

Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Purcarea, Anna; Jarosch, Sebastian; Barton, Jack; Grassmann, Simon; Pachmayr, Ludwig; D'Ippolito, Elvira; Hammel, Monika; Hochholzer, Anna; Wagner, Karolin I; van den Berg, Joost H; Buchholz, Veit R; Haanen, John B A G; Busch, Dirk H; Schober, Kilian
Abstract:
T cell receptor (TCR) avidity is assumed to be a major determinant of the spatiotemporal fate and protective capacity of tumor-specific T cells. However, monitoring polyclonal T cell responses with known TCR avidities in vivo over space and time remains challenging. Here, we investigated the fate and functionality of tumor neoantigen-specific T cells with TCRs of distinct avidities in a well-established, reductionist preclinical tumor model and human patients with melanoma. To this end, we used...     »
Journal title abbreviation:
Sci Immunol
Year:
2022
Journal volume:
7
Journal issue:
74
Fulltext / DOI:
doi:10.1126/sciimmunol.abm2077
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35960818
Print-ISSN:
2470-9468
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Urologie
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