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Title:

Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Vejzagić, Nermina; Prodjinotho, Ulrich Fabien; El-Khafif, Nagwa; Huang, Ruili; Simeonov, Anton; Spangenberg, Thomas; Prazeres da Costa, Clarissa
Abstract:
BACKGROUND: Anthelminthic treatment options against schistosomiasis are limited. The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). As a consequence, the development of resistance to PZQ and limited activity of PZQ against earlier development stages are respectively a risk and a limitation to achieving the goals of the new WHO roadmap towards elimination. For the discovery of new chemical starting points, the in vitro drug screening on Schistosoma mansoni (S. m...     »
Journal title abbreviation:
PLoS Negl Trop Dis
Year:
2021
Journal volume:
15
Journal issue:
5
Fulltext / DOI:
doi:10.1371/journal.pntd.0009432
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34033658
Print-ISSN:
1935-2727
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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