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Title:

Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice.

Document type:
Journal Article
Author(s):
Xie, Kan; Ryan, Devon P; Pearson, Brandon L; Henzel, Kristin S; Neff, Frauke; Vidal, Ramon O; Hennion, Magali; Lehmann, Isabelle; Schleif, Melvin; Schröder, Susanne; Adler, Thure; Rathkolb, Birgit; Rozman, Jan; Schütz, Anna-Lena; Prehn, Cornelia; Mickael, Michel E; Weiergräber, Marco; Adamski, Jerzy; Busch, Dirk H; Ehninger, Gerhard; Matynia, Anna; Jackson, Walker S; Wolf, Eckhard; Fuchs, Helmut; Gailus-Durner, Valerie; Bonn, Stefan; Hrab? de Angelis, Martin; Ehninger, Dan
Abstract:
Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next generation. In humans, advanced paternal age has been associated with increased risk for a number of diseases. Experiments in rodent models have provided initial evidence that paternal age can influence behavioral traits in offspring animals, but the overall scope and extent of paternal age effects on health and disease across the life span...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2018
Journal volume:
115
Journal issue:
10
Pages contribution:
E2348-E2357
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1707337115
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29467291
Print-ISSN:
0027-8424
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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