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Titel:

MYB orchestrates T cell exhaustion and response to checkpoint inhibition.

Dokumenttyp:
Journal Article
Autor(en):
Tsui, Carlson; Kretschmer, Lorenz; Rapelius, Svenja; Gabriel, Sarah S; Chisanga, David; Knöpper, Konrad; Utzschneider, Daniel T; Nüssing, Simone; Liao, Yang; Mason, Teisha; Torres, Santiago Valle; Wilcox, Stephen A; Kanev, Krystian; Jarosch, Sebastian; Leube, Justin; Nutt, Stephen L; Zehn, Dietmar; Parish, Ian A; Kastenmüller, Wolfgang; Shi, Wei; Buchholz, Veit R; Kallies, Axel
Abstract:
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of restrained functionality-which is referred to as T cell exhaustion1,2-is maintained by precursors of exhausted T (TPEX) cells that express the transcription factor T cell factor 1 (TCF1), self-renew and give rise to TCF1- exhausted effector T cells3-6. Here we show that...     »
Zeitschriftentitel:
Nature
Jahr:
2022
Band / Volume:
609
Heft / Issue:
7926
Seitenangaben Beitrag:
354-360
Volltext / DOI:
doi:10.1038/s41586-022-05105-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35978192
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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