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Title:

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.

Document type:
Journal Article; Article
Author(s):
Bernhard, H; Neudorfer, J; Gebhard, K; Conrad, H; Hermann, C; Nährig, J; Fend, F; Weber, W; Busch, DH; Peschel, C
Abstract:
The human epidermal growth factor receptor 2 (HER2) has been targeted as a breast cancer-associated antigen by immunotherapeutical approaches based on HER2-directed monoclonal antibodies and cancer vaccines. We describe the adoptive transfer of autologous HER2-specific T-lymphocyte clones to a patient with metastatic HER2-overexpressing breast cancer. The HLA/multimer-based monitoring of the transferred T lymphocytes revealed that the T cells rapidly disappeared from the peripheral blood. The im...     »
Journal title abbreviation:
Cancer Immunol Immunother
Year:
2008
Journal volume:
57
Journal issue:
2
Pages contribution:
271-80
Language:
eng
Fulltext / DOI:
doi:10.1007/s00262-007-0355-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17646988
Print-ISSN:
0340-7004
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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