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Titel:

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bonifacius, Agnes; Lamottke, Britta; Tischer-Zimmermann, Sabine; Schultze-Florey, Rebecca; Goudeva, Lilia; Heuft, Hans-Gert; Arseniev, Lubomir; Beier, Rita; Beutel, Gernot; Cario, Gunnar; Fröhlich, Birgit; Greil, Johann; Hansmann, Leo; Hasenkamp, Justin; Höfs, Michaela; Hundsdoerfer, Patrick; Jost, Edgar; Kafa, Kinan; Kriege, Oliver; Kröger, Nicolaus; Mathas, Stephan; Meisel, Roland; Nathrath, Michaela; Putkonen, Mervi; Ravens, Sarina; Reinhardt, Hans Christian; Sala, Elisa; Sauer, Martin G; Sch...     »
Abstract:
BACKGROUNDAdoptive transfer of EBV-specific T cells can restore specific immunity in immunocompromised patients with EBV-associated complications.METHODSWe provide results of a personalized T cell manufacturing program evaluating donor, patient, T cell product, and outcome data. Patient-tailored clinical-grade EBV-specific cytotoxic T lymphocyte (EBV-CTL) products from stem cell donors (SCDs), related third-party donors (TPDs), or unrelated TPDs from the allogeneic T cell donor registry (alloCEL...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2023
Band / Volume:
133
Heft / Issue:
12
Volltext / DOI:
doi:10.1172/JCI163548
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37159273
Print-ISSN:
0021-9738
TUM Einrichtung:
1461; 1605; 290; Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)
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