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Titel:

Role of ?1 integrins and bacterial adhesins for Yop injection into leukocytes in Yersinia enterocolitica systemic mouse infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Deuschle, Eva; Keller, Birgit; Siegfried, Alexandra; Manncke, Birgit; Spaeth, Tanja; Köberle, Martin; Drechsler-Hake, Doreen; Reber, Julia; Böttcher, Ralph T; Autenrieth, Stella E; Autenrieth, Ingo B; Bohn, Erwin; Schütz, Monika
Abstract:
Injection of Yersinia outer proteins (Yops) into host cells by a type III secretion system is an important immune evasion mechanism of Yersinia enterocolitica (Ye). In this process Ye invasin (Inv) binds directly while Yersinia adhesin A (YadA) binds indirectly via extracellular matrix (ECM) proteins to ?1 integrins on host cells. Although leukocytes turned out to be an important target of Yop injection by Ye, it was unclear which Ye adhesins and which leukocyte receptors are required for Yop in...     »
Zeitschriftentitel:
Int J Med Microbiol
Jahr:
2016
Band / Volume:
306
Heft / Issue:
2
Seitenangaben Beitrag:
77-88
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ijmm.2015.12.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26718660
Print-ISSN:
1438-4221
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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