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Title:

The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Thorey, I S; Roth, J; Regenbogen, J; Halle, J P; Bittner, M; Vogl, T; Kaesler, S; Bugnon, P; Reitmaier, B; Durka, S; Graf, A; Wöckner, M; Rieger, N; Konstantinow, A; Wolf, E; Goppelt, A; Werner, S
Abstract:
To gain insight into the molecular mechanisms underlying cutaneous wound repair, we performed a large scale screen to identify novel injury-regulated genes. Here we show a strong up-regulation of the RNA and protein levels of the two Ca(2+)-binding proteins S100A8 and S100A9 in the hyperthickened epidermis of acute murine and human wounds and of human ulcers. Furthermore, both genes were expressed by inflammatory cells in the wound. The increased expression of S100A8 and S100A9 in wound keratino...     »
Journal title abbreviation:
J Biol Chem
Year:
2001
Journal volume:
276
Journal issue:
38
Pages contribution:
35818-25
Fulltext / DOI:
doi:10.1074/jbc.M104871200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/11463791
Print-ISSN:
0021-9258
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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