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Titel:

Proposed European Competence Network on Mastocytosis-American Initiative in Mast Cell Diseases (ECNM-AIM) Response Criteria in Advanced Systemic Mastocytosis.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Autor(en):
Gotlib, Jason; Schwaab, Juliana; Shomali, William; George, Tracy I; Radia, Deepti H; Castells, Mariana; Carter, Melody C; Hartmann, Karin; Álvarez-Twose, Ivan; Brockow, Knut; Bonadonna, Patrizia; Hermine, Olivier; Niedoszytko, Marek; Hoermann, Gregor; Sperr, Wolfgang R; Elberink, Hanneke Oude; Siebenhaar, Frank; Butterfield, Joseph H; Ustun, Celalettin; Zanotti, Roberta; Triggiani, Massimo; Schwartz, Lawrence B; Lyons, Jonathan J; Orfao, Alberto; Sotlar, Karl; Horny, Hans-Peter; Arock, Michel; M...     »
Abstract:
Advanced systemic mastocytosis (AdvSM) is characterized by the presence of KIT D816V and other somatic mutations (eg, in SRSF2, ASXL1, and RUNX1) in 95% and 60% to 70% of patients, respectively. The biological and clinical consequences of AdvSM include multilineage involvement (eg, associated hematologic neoplasm) in 60% to 80% of patients, variable infiltration and damage (C-findings) of predominantly bone marrow and visceral organs through affected mast cell (MC) and non-MC lineages, and eleva...     »
Zeitschriftentitel:
J Allergy Clin Immunol Pract
Jahr:
2022
Band / Volume:
10
Heft / Issue:
8
Seitenangaben Beitrag:
2025-2038.e1
Volltext / DOI:
doi:10.1016/j.jaip.2022.05.034
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35724948
Print-ISSN:
2213-2198
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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