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Titel:

Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.

Dokumenttyp:
Article; Journal Article; Comparative Study
Autor(en):
Wisch, Julie K; McKay, Nicole S; Zammit, Matthew; Christian, Bradley T; Schultz, Stephanie A; Millar, Peter R; Ryan, Natalie S; Cash, David M; Belder, Christopher R S; Chrem, Patricio; Cruchaga, Carlos; Ibanez, Laura; Jucker, Mathias; Yakushev, Igor; Day, Gregory S; Murphy, Mei; Llibre-Guerra, Jorge; Aguillon, David; Roh, Jee Hoon; Xiong, Chengjie; Wang, Guoqiao; Li, Yan; Schindler, Suzanne E; Jack, Cliff; McDade, Eric; Bateman, Randall J; Benzinger, Tammie L S; Ances, Beau M; Betthauser, Tobey;...     »
Abstract:
INTRODUCTION: Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time. METHODS: We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal autosomal dominant AD (ADAD) sample (N = 379) with amyloid positron emission tomography. We compared (1) predicted age at A+ to imputed age, (2) estimated age at A+ to estimated age at symptom onset, and (3) variance in cognitive performance explained. RESULTS: Mean error between imputed and SILA-estimated age at A+ (N = 26) was 1.15 years. Age at A+ explained 39% of estimated years to symptom onset (EYO) variance. Time from A+ explained 19% of cognitive composite variance and 14% of Clinical Dementia Rating Sum of Boxes CDR-SB variance; EYO explained 43% and 57%, respectively. DISCUSSION: SILA estimates A+ age in ADAD with reasonably good accuracy. SILA-estimated time from A+ describes the start of pathology, but the time from A+ onset to symptoms is variable in ADAD and better described by EYO. HIGHLIGHTS: Amyloid chronicity predicts a 14-year preclinical AD phase in ADAD. SILA accurately estimates age at A+ (MAE < 2 years). EYO outperforms chronicity in predicting symptom onset. APP mutation carriers show atypical amyloid accumulation. Chronicity models help reveal AD heterogeneity in preclinical stages.
Zeitschriftentitel:
Alzheimers Dement
Jahr:
2025
Band / Volume:
21
Heft / Issue:
10
Volltext / DOI:
doi:10.1002/alz.70812
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/41137622
Print-ISSN:
1552-5260
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
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