A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy.

Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, CuiCi; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till F M; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan S; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid; Hemmer, Bernhard; Mühlau, Mark

doi:10.1002/ana.26807

Klinik und Poliklinik für Neurologie (Prof. Hemmer)

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Dokumenttyp:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):: Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, CuiCi; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till F M; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan S; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid; Hemmer, Bernhard; Mühlau, Mark
Titel:: A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy.
Abstract:: The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more brain atrophy per rs10191329*A allele. Our results encourage stratification for rs10191329 in clinical trials. Unraveling the underlying mechanisms may enhance our understanding of pathophysiology and identify treatment targets. ANN NEUROL 2023; 94:1080-1085. «
The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more brain atrophy per rs10191329*A allele. Our results encourage stratification for rs10191... »
Zeitschriftentitel:: Ann Neurol
Jahr:: 2023
Band / Volume:: 94
Heft / Issue:: 6
Seitenangaben Beitrag:: 1080-1085
Volltext / DOI:: doi:10.1002/ana.26807
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/37753809
Print-ISSN:: 0364-5134
TUM Einrichtung:: Klinik und Poliklinik für Neurologie (Prof. Hemmer); Professur für Neuroradiologie (Prof. Zimmer)
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