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Titel:

A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, CuiCi; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till F M; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan S; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid; Hemmer, Bernhard; Mühlau, Mark
Abstract:
The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more brain atrophy per rs10191329*A allele. Our results encourage stratification for rs10191...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2023
Band / Volume:
94
Heft / Issue:
6
Seitenangaben Beitrag:
1080-1085
Volltext / DOI:
doi:10.1002/ana.26807
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37753809
Print-ISSN:
0364-5134
TUM Einrichtung:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Professur für AI for Image-Guided Diagnosis and Therapy (Prof. Wiestler); Professur für Neuroradiologie (Prof. Zimmer)
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