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Title:

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Linnerbauer, Mathias; Beyer, Tobias; Nirschl, Lucy; Farrenkopf, Daniel; Lößlein, Lena; Vandrey, Oliver; Peter, Anne; Tsaktanis, Thanos; Kebir, Hania; Laplaud, David; Oellinger, Rupert; Engleitner, Thomas; Alvarez, Jorge Ivan; Rad, Roland; Korn, Thomas; Hemmer, Bernhard; Quintana, Francisco J; Rothhammer, Veit
Abstract:
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central nervous system (CNS). Current therapies mainly target inflammatory processes during acute stages, but effective treatments for progressive MS are limited. In this context, astrocytes have gained increasing attention as they have the capacity to drive, but also suppress tissue-degeneration. Here we show that astrocytes upregulate the immunomodulatory checkpoint molecule PD-L1 during acute autoimmune CNS inflammat...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-40982-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37689786
Print-ISSN:
2041-1723
TUM Institution:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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