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Titel:

Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Stemmler, HJ; Schmitt, M; Willems, A; Bernhard, H; Harbeck, N; Heinemann, V
Abstract:
Patients receiving trastuzumab for HER2-overexpressing metastatic breast cancer seem to suffer from an increased risk of brain metastases, even in cases with responsive disease. To evaluate whether trastuzumab is able to penetrate the blood-brain barrier, we measured trastuzumab levels in the serum and in cerebrospinal fluid of metastatic breast cancer patients with brain metastases receiving trastuzumab for HER2-overexpressing metastatic breast cancer. In a pilot study, metastatic breast cancer...     »
Zeitschriftentitel:
Anticancer Drugs
Jahr:
2007
Band / Volume:
18
Heft / Issue:
1
Seitenangaben Beitrag:
23-8
Sprache:
eng
Volltext / DOI:
doi:10.1097/01.cad.0000236313.50833.ee
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17159499
Print-ISSN:
0959-4973
TUM Einrichtung:
Frauenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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