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Title:

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

Document type:
Zeitschriftenaufsatz
Author(s):
Jin, Kelly; Wilson, Kenneth A.; Beck, Jennifer N.; Nelson, Christopher S.; Brownridge, George W.; Harrison, Benjamin R.; Djukovic, Danijel; Raftery, Daniel; Brem, Rachel B.; Yu, Shiqing; Drton, Mathias; Shojaie, Ali; Kapahi, Pankaj; Promislow, Daniel
Abstract:
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were associated with the magnitude of the lifespan response. These included proteinogenic a...     »
Dewey Decimal Classification:
510 Mathematik
Journal title:
PLOS Genetics
Year:
2020
Journal volume:
16
Year / month:
2020-07
Quarter:
3. Quartal
Month:
Jul
Journal issue:
7
Pages contribution:
e1008835
Language:
en
Fulltext / DOI:
doi:10.1371/journal.pgen.1008835
WWW:
PLOS Genetics
Publisher:
Public Library of Science (PLoS)
Print-ISSN:
1553-7390
E-ISSN:
1553-7404
Submitted:
08.01.2020
Accepted:
06.05.2020
Date of publication:
09.07.2020
Semester:
SS 20
TUM Institution:
Lehrstuhl für Mathematische Statistik
Format:
Text
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