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Titel:

Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance

Dokumenttyp:
Buchbeitrag
Autor(en):
Pérez-Velázquez, Judith; Gevertz, Jana L.; Karolak, Aleksandra; Rejniak, Katarzyna A.
Abstract:
A tumor vasculature that is functionally abnormal results in irregular gradients of metabolites and drugs within the tumor tissue. Recently, significant efforts have been committed to experimentally examine how cellular response to anti-cancer treatments varies based on the environment in which the cells are grown. In vitro studies point to specific conditions in which tumor cells can remain dormant and survive the treatment. In vivo results suggest that cells can escape the effects of drug ther...     »
Seitenangaben Beitrag:
149--164
Herausgeber:
Rejniak, Katarzyna A.
Buchtitel:
Systems Biology of Tumor Microenvironment: Quantitative Modeling and Simulations
Verlag / Institution:
Springer International Publishing
Verlagsort:
Cham
Jahr:
2016
Print-ISBN:
978-3-319-42023-3
DOI:
doi:10.1007/978-3-319-42023-3_8
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