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- Original title:
- Intestinal amino acid absorption and control of transepithelial transport – Filling the gaps
- Translated title:
- Intestinale Aufnahme von Aminosäuren und Kontrolle des transepithelialen Transports
- Author:
- Rohm, Florian Peter
- Year:
- 2022
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Life Sciences
- Advisor:
- Skurk, Thomas (Prof. Dr.)
- Referee:
- Skurk, Thomas (Prof. Dr.); Witt, Heiko (Prof. Dr.)
- Language:
- en
- Subject group:
- OEK Ökotrophologie, Ernährungswissenschaft
- Keywords:
- PEPT1, protein, dipeptides, tripeptides, hydrolysis, transport
- Translated keywords:
- PEPT1, Protein, Dipeptide, Tripeptide, Hydrolyse, Transport
- TUM classification:
- OEK 160
- Abstract:
- The systematic quantification of di- and tripeptides revealed postprandial human plasma levels that do not correlate with the peptides’ affinity to PEPT1. In transport and hydrolysis studies in different intestinal models, structure dependent susceptibilities to hydrolysis at the brush border membrane and within enterocytes vary greatly between oligopeptides, but they are almost identical across tested models.
- Translated abstract:
- Die systematische Quantifizierung von Di- und Tripeptiden ergab postprandiale humane Plasmaspiegel, die der Affinität der Peptide zu PEPT1 nicht entsprechen. In Transport- und Hydrolysestudien in verschiedenen Darmmodellen variieren die strukturabhängigen Hydrolyseanfälligkeiten an der Bürstensaummembran und innerhalb von Enterozyten stark zwischen einzelnen Peptiden, wobei sie in allen getesteten Modellen nahezu identisch sind.
- WWW:
- https://mediatum.ub.tum.de/?id=1647011
- Date of submission:
- 12.04.2022
- Oral examination:
- 28.10.2022
- File size:
- 17958789 bytes
- Pages:
- 126
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20221028-1647011-1-8
- Last change:
- 21.11.2022
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