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Original title:
Targeted and non-targeted studies on Alternaria alternata metabolites 
Translated title:
Targeted und non-targeted Studien zu Metaboliten von Alternaria alternata 
Year:
2020 
Document type:
Dissertation 
Institution:
Fakultät Wissenschaftszentrum Weihenstephan 
Advisor:
Rychlik, Michael (Prof. Dr.) 
Referee:
Rychlik, Michael (Prof. Dr.); Engel, Karl-Heinz (Prof. Dr.) 
Language:
en 
Subject group:
BIO Biowissenschaften; CHE Chemie 
Keywords:
Alternaria alternata, fungi, mycotoxins, AOH, AME, ATX I, ALTP, TEN, TA, alterperylenepoxide A 9-mercaptolactate (APML), LC-MS/MS, stable isotope dilution assay (SIDA), infant food, non-targeted, metabolomics, FT-ICR-MS 
Translated keywords:
Alternaria alternata, Schimmelpilze, Mykotoxine, AOH, AME, ATX I, ALTP, TEN, TA, Alterperylenepoxid A 9-Mercaptolactat (APML), LC-MS/MS, Stabilisotopenverdünnungsanalyse (SIVA), Babynahrung, non-targeted, Metabolomics, FT-ICR-MS 
TUM classification:
LEB 050d 
Abstract:
Fungi of the genus Alternaria are widely occurring plant pathogens infecting a multitude of crops, fruits, and vegetables. In the present thesis, a sensitive LC-MS/MS method for the accurate quantification of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, tentoxin, altertoxin I, alterperylenol, and tenuazonic acid in various foods was developed. Besides, non-targeted metabolomics investigations were conducted by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to obtain deeper insights into the mycobolome of Alternaria fungi. 
Translated abstract:
Schimmelpilze der Gattung Alternaria sind weit verbreitete Pflanzenpathogene, die eine Vielzahl an Getreide-, Obst- und Gemüsesorten befallen. Die vorliegende Arbeit umfasst die Entwicklung einer sensitiven LC-MS/MS-Methode zur exakten Quantifizierung der Alternaria-Mykotoxine Alternariol, Alternariol-Monomethylether, Tentoxin, Altertoxin I, Alterperylenol und Tenuazonsäure in verschiedenen Lebensmitteln. Um tiefergehende Einblicke in das Metabolom von Alternaria-Pilzen zu erhalten, wurden non-...    »
 
Oral examination:
26.10.2020 
File size:
15290191 bytes 
Pages:
201 
Last change:
03.12.2020