By using HPIC and LC-MS/MS as well as SDS-PAGE followed by tryptic digestion and nano-LC-MS/MS the influence of dietary chemosensates on saliva metabolome and proteome was analyzed. Relative protein quantitation was applied and by gene ontology enrichment analysis the functional changes in the saliva proteome were investigated. Functional assays and sensory experiments were carried out and the increased antimicrobial activity of saliva samples after chemosensory stimulation as well the influence of the stimulation on odorant as well as salt taste perception were shown for the first time.
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