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Titel:

Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome.

Dokumenttyp:
Article; Journal Article
Autor(en):
Vinnakota, Janaki Manoja; Biavasco, Francesca; Schwabenland, Marius; Chhatbar, Chintan; Adams, Rachael C; Erny, Daniel; Duquesne, Sandra; El Khawanky, Nadia; Schmidt, Dominik; Fetsch, Viktor; Zähringer, Alexander; Salié, Henrike; Athanassopoulos, Dimitrios; Braun, Lukas M; Javorniczky, Nora R; Ho, Jenny N H G; Kierdorf, Katrin; Marks, Reinhard; Wäsch, Ralph; Simonetta, Federico; Andrieux, Geoffroy; Pfeifer, Dietmar; Monaco, Gianni; Capitini, Christian; Fry, Terry J; Blank, Thomas; Blazar, Bruce...     »
Abstract:
Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity syndrome (ICANS). However, the molecular mechanisms leading to ICANS are not well understood. Here we examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits. The TGFβ-activated kinase-1 (TAK1)-NF-κB-p38 MAPK pathwa...     »
Zeitschriftentitel:
Nat. Cancer
Jahr:
2024
Band / Volume:
5
Heft / Issue:
8
Seitenangaben Beitrag:
1227-1249
Volltext / DOI:
doi:10.1038/s43018-024-00764-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38741011
TUM Einrichtung:
608; Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Klinik und Poliklinik für Psychiatrie und Psychotherapie (Prof. Priller)
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