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Title:

Neurotoxin-Derived Optical Probes for Elucidating Molecular and Developmental Biology of Neurons and Synaptic Connections : Toxin-Derived Optical Probes for Neuroimaging.

Document type:
Journal Article; Review
Author(s):
Bijjam, Rohini; Shorter, Susan; Bratt, Alison M; O'Leary, Valerie B; Ntziachristos, Vasilis; Ovsepian, Saak Victor
Abstract:
Botulinum neurotoxins (BoNTs) and tetanus toxin (TeTX) are the deadliest biological substances that cause botulism and tetanus, respectively. Their astonishing potency and capacity to enter neurons and interfere with neurotransmitter release at presynaptic terminals have attracted much interest in experimental neurobiology and clinical research. Fused with reporter proteins or labelled with fluorophores, BoNTs and TeTX and their non-toxic fragments also offer remarkable opportunities to visualiz...     »
Journal title abbreviation:
Mol Imaging Biol
Year:
2024
Fulltext / DOI:
doi:10.1007/s11307-024-01954-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/39348040
Print-ISSN:
1536-1632
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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