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Titel:

Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST).

Dokumenttyp:
Journal Article
Autor(en):
Rassner, Michael; Waldeck, Silvia; Follo, Marie; Jilg, Stefanie; Philipp, Ulrike; Jolic, Martina; Wehrle, Julius; Jost, Philipp J; Peschel, Christian; Illert, Anna Lena; Duyster, Justus; Scherer, Florian; von Bubnoff, Nikolas
Abstract:
BACKGROUND: Mutations in cKIT or PDGFRA are found in up to 90% of patients with gastrointestinal stromal tumors (GISTs). Previously, we described the design, validation, and clinical performance of a digital droplet (dd)PCR assay panel for the detection of imatinib-sensitive cKIT and PDFGRA mutations in circulating tumor (ct)DNA. In this study, we developed and validated a set of ddPCR assays for the detection of cKIT mutations mediating resistance to cKIT kinase inhibitors in ctDNA. In addition...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2023
Band / Volume:
24
Heft / Issue:
6
Volltext / DOI:
doi:10.3390/ijms24065411
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36982486
Print-ISSN:
1422-0067
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Professur für Personalisierte Onkologie (Prof. Illert)
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