Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm.

Becker von Rose, Aaron; Kobus, Kathrin; Bohmann, Bianca; Lindquist-Lilljequist, Moritz; Eilenberg, Wolf; Kapalla, Marvin; Bassermann, Florian; Reeps, Christian; Eckstein, Hans-Henning; Neumayer, Christoph; Brostjan, Christine; Roy, Joy; von Heckel, Korbinian; Hultgren, Rebecka; Schwaiger, Benedikt J; Combs, Stephanie E; Busch, Albert; Schiller, Kilian

doi:10.1007/s00066-023-02135-0

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2024

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Title:: Radiation therapy for cancer is potentially associated with reduced growth of concomitant abdominal aortic aneurysm.
Document type:: Journal Article
Author(s):: Becker von Rose, Aaron; Kobus, Kathrin; Bohmann, Bianca; Lindquist-Lilljequist, Moritz; Eilenberg, Wolf; Kapalla, Marvin; Bassermann, Florian; Reeps, Christian; Eckstein, Hans-Henning; Neumayer, Christoph; Brostjan, Christine; Roy, Joy; von Heckel, Korbinian; Hultgren, Rebecka; Schwaiger, Benedikt J; Combs, Stephanie E; Busch, Albert; Schiller, Kilian
Abstract:: PURPOSE: Co-prevalence of abdominal aortic aneurysm (AAA) and cancer poses a unique challenge in medical care since both diseases and their respective therapies might interact. Recently, reduced AAA growth rates were observed in cancer patients that received radiation therapy (RT). The purpose of this study was to perform a fine-grained analysis of the effects of RT on AAA growth with respect to direct (infield) and out-of-field (outfield) radiation exposure, and radiation dose-dependency. METHODS: A retrospective single-center analysis identified patients with AAA, cancer, and RT. Clinical data, radiation plans, and aneurysm diameters were analyzed. The total dose of radiation to each aneurysm was computed. AAA growth under infield and outfield exposure was compared to patients with AAA and cancer that did not receive RT (no-RT control) and to an external noncancer AAA reference cohort. RESULTS: Between 2003 and 2020, a total of 38 AAA patients who had received well-documented RT for their malignancy were identified. AAA growth was considerably reduced for infield patients (n = 18) compared to outfield patients (n = 20), albeit not significantly (0.8 ± 1.0 vs. 1.3 ± 1.6 mm/year, p = 0.28). Overall, annual AAA growth in RT patients was lower compared to no-RT control patients (1.1 ± 1.5 vs. 1.8 ± 2.2 mm/year, p = 0.06) and significantly reduced compared to the reference cohort (1.1 ± 1.5 vs. 2.7 ± 2.1 mm/year, p < 0.001). The pattern of AAA growth reduction due to RT was corroborated in linear regression analyses correcting for initial AAA diameter. A further investigation with respect to dose-dependency of radiation effects on AAA growth, however, revealed no apparent association. CONCLUSION: In this study, both infield and outfield radiation exposure were associated with reduced AAA growth. This finding warrants further investigation, both in a larger scale clinical cohort and on a molecular level.
Journal title abbreviation:: Strahlenther Onkol
Year:: 2024
Journal volume:: 200
Journal issue:: 5
Pages contribution:: 425-433
Fulltext / DOI:: doi:10.1007/s00066-023-02135-0
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37676483
Print-ISSN:: 0179-7158
TUM Institution:: Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie (Prof. Bassermann); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs); Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie (Prof. Eckstein)
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