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Titel:

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Autor(en):
Jiang, Zhengyu; Wu, Feijing; Laise, Pasquale; Takayuki, Tanaka; Na, Fu; Kim, Woosook; Kobayashi, Hiroki; Chang, Wenju; Takahashi, Ryota; Valenti, Giovanni; Sunagawa, Masaki; White, Ruth A; Macchini, Marina; Renz, Bernhard W; Middelhoff, Moritz; Hayakawa, Yoku; Dubeykovskaya, Zinaida A; Tan, Xiangtian; Chu, Timothy H; Nagar, Karan; Tailor, Yagnesh; Belin, Bryana R; Anand, Akanksha; Asfaha, Samuel; Finlayson, Michael O; Iuga, Alina C; Califano, Andrea; Wang, Timothy C
Abstract:
While adult pancreatic stem cells are thought not to exist, it is now appreciated that the acinar compartment harbors progenitors, including tissue-repairing facultative progenitors (FPs). Here, we study a pancreatic acinar population marked by trefoil factor 2 (Tff2) expression. Long-term lineage tracing and single-cell RNA sequencing (scRNA-seq) analysis of Tff2-DTR-CreERT2-targeted cells defines a transit-amplifying progenitor (TAP) population that contributes to normal homeostasis. Following...     »
Zeitschriftentitel:
Cell Stem Cell
Jahr:
2023
Band / Volume:
30
Heft / Issue:
8
Seitenangaben Beitrag:
1091-1109.e7
Volltext / DOI:
doi:10.1016/j.stem.2023.07.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37541213
Print-ISSN:
1934-5909
TUM Einrichtung:
591; Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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