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Title:

Surface plasmon resonance assays for the therapeutic drug monitoring of infliximab indicate clinical relevance of anti-infliximab antibody binding properties.

Document type:
Journal Article
Author(s):
Grasmeier, Melina K; Weber, Susanne; Treiber, Matthias; Thaler, Markus A; Luppa, Peter B
Abstract:
OBJECTIVES: The therapeutic antibody infliximab (IFX) has improved the life quality of numerous autoinflammatory disease patients. However, IFX can trigger the generation of anti-drug antibodies (ADA), whose optimal evaluation and management are currently subject of controversial discussions. We present two novel surface plasmon resonance (SPR) biosensor assays for therapeutic drug monitoring of IFX and characterization of ADA and investigated the diagnostic value of ADA binding properties. METH...     »
Journal title abbreviation:
Clin Chem Lab Med
Year:
2023
Journal volume:
61
Journal issue:
7
Pages contribution:
1255-1265
Fulltext / DOI:
doi:10.1515/cclm-2022-0949
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36753693
Print-ISSN:
1434-6621
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie (Prof. Ruland); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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