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Dokumenttyp:
Preprint
Autor(en):
Drexler, Richard; Khatri, Robin; Sauvigny, Thomas; Mohme, Malte; Maire, Cecile L; Ryba, Alice; Zghaibeh, Yahya; Dührsen, Lasse; Salviano-Silva, Amanda; Lamszus, Katrin; Westphal, Manfred; Gempt, Jens; Wefers, Annika K; Neumann, Julia; Bode, Helena; Hausmann, Fabian; Huber, Tobias B; Bonn, Stefan; Jütten, Kerstin; Delev, Daniel; Weber, Katharina J; Harter, Patrick N; Onken, Julia; Vajkoczy, Peter; Capper, David; Wiestler, Benedikt; Weller, Michael; Snijder, Berend; Buck, Alicia; Weiss, Tobias; Ke...     »
Titel:
Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability.
Abstract:
Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is nascent. We present an epigenetically defined neural signature of glioblastoma that independently affects patients' survival. We use reference signatures of neural cells to deconvolve tumor DNA and classify samples into low- or high-neural tumors. High-neural glioblastomas exhibit hypomethylated CpG sites and upregulation of genes associated with synaptic integration. Single-cell transcri...     »
Zeitschriftentitel:
bioRxiv
Jahr:
2023
Volltext / DOI:
doi:10.1101/2023.08.04.552017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37609137
TUM Einrichtung:
Professur für AI for Image-Guided Diagnosis and Therapy (Prof. Wiestler)
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