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Title:

Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Emslander, Quirin; Vogele, Kilian; Braun, Peter; Stender, Jana; Willy, Christian; Joppich, Markus; Hammerl, Jens A; Abele, Miriam; Meng, Chen; Pichlmair, Andreas; Ludwig, Christina; Bugert, Joachim J; Simmel, Friedrich C; Westmeyer, Gil G
Abstract:
Bacteriophages are potent therapeutics against biohazardous bacteria, which rapidly develop multidrug resistance. However, routine administration of phage therapy is hampered by a lack of rapid production, safe bioengineering, and detailed characterization of phages. Thus, we demonstrate a comprehensive cell-free platform for personalized production, transient engineering, and proteomic characterization of a broad spectrum of phages. Using mass spectrometry, we validated hypothetical and non-str...     »
Journal title abbreviation:
Cell Chem Biol
Year:
2022
Journal volume:
29
Journal issue:
9
Pages contribution:
1434-1445.e7
Fulltext / DOI:
doi:10.1016/j.chembiol.2022.06.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35820417
Print-ISSN:
2451-9456
TUM Institution:
Institut für Virologie (Prof. Protzer)
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