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Titel:

Neurotoxin-Derived Optical Probes for Elucidating Molecular and Developmental Biology of Neurons and Synaptic Connections : Toxin-Derived Optical Probes for Neuroimaging.

Dokumenttyp:
Journal Article; Review
Autor(en):
Bijjam, Rohini; Shorter, Susan; Bratt, Alison M; O'Leary, Valerie B; Ntziachristos, Vasilis; Ovsepian, Saak Victor
Abstract:
Botulinum neurotoxins (BoNTs) and tetanus toxin (TeTX) are the deadliest biological substances that cause botulism and tetanus, respectively. Their astonishing potency and capacity to enter neurons and interfere with neurotransmitter release at presynaptic terminals have attracted much interest in experimental neurobiology and clinical research. Fused with reporter proteins or labelled with fluorophores, BoNTs and TeTX and their non-toxic fragments also offer remarkable opportunities to visualiz...     »
Zeitschriftentitel:
Mol Imaging Biol
Jahr:
2024
Volltext / DOI:
doi:10.1007/s11307-024-01954-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/39348040
Print-ISSN:
1536-1632
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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