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Title:

Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Grimm, Christina; Frässle, Stefan; Steger, Céline; von Ziegler, Lukas; Sturman, Oliver; Shemesh, Noam; Peleg-Raibstein, Daria; Burdakov, Denis; Bohacek, Johannes; Stephan, Klaas Enno; Razansky, Daniel; Wenderoth, Nicole; Zerbi, Valerio
Abstract:
The basal ganglia (BG) are a group of subcortical nuclei responsible for motor and executive function. Central to BG function are striatal cells expressing D1 (D1R) and D2 (D2R) dopamine receptors. D1R and D2R cells are considered functional antagonists that facilitate voluntary movements and inhibit competing motor patterns, respectively. However, whether they maintain a uniform function across the striatum and what influence they exert outside the BG is unclear. Here, we address these question...     »
Journal title:
Cell Reports
Journal title abbreviation:
Cell Rep
Year:
2021
Journal volume:
37
Journal issue:
13
Fulltext / DOI:
doi:10.1016/j.celrep.2021.110161
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34965430
WWW:
https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01657-0
Print-ISSN:
2211-1247
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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