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Title:

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics

Document type:
Zeitschriftenaufsatz
Author(s):
Lee, Chien-Yun; The, Matthew; Meng, Chen; Bayer, Florian P; Putzker, Kerstin; Müller, Julian; Streubel, Johanna; Woortman, Julia; Sakhteman, Amirhossein; Resch, Moritz; Schneider, Annika; Wilhelm, Stephanie; Kuster, Bernhard
Abstract:
Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellular proteotypes of sarcoma cells shape their response to molecularly targeted drugs, we profiled the proteomes and phosphoproteomes of 17 sarcoma cell lines and screened the same against 150 cancer dr...     »
Keywords:
BayBioMS; Drug Response; Kinase Inhibitor; Phosphoproteomics; Proteomics; Sarcoma
Journal title:
Molecular Systems Biology
Year:
2023
Journal volume:
20
Journal issue:
1
Pages contribution:
28-55
Fulltext / DOI:
doi:10.1038/s44320-023-00004-7
Publisher:
Springer Science and Business Media LLC
E-ISSN:
1744-4292
Date of publication:
18.12.2023
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