Benutzer: Gast  Login
Titel:

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Lee, Chien-Yun; The, Matthew; Meng, Chen; Bayer, Florian P; Putzker, Kerstin; Müller, Julian; Streubel, Johanna; Woortman, Julia; Sakhteman, Amirhossein; Resch, Moritz; Schneider, Annika; Wilhelm, Stephanie; Kuster, Bernhard
Abstract:
Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellular proteotypes of sarcoma cells shape their response to molecularly targeted drugs, we profiled the proteomes and phosphoproteomes of 17 sarcoma cell lines and screened the same against 150 cancer dr...     »
Stichworte:
BayBioMS; Drug Response; Kinase Inhibitor; Phosphoproteomics; Proteomics; Sarcoma
Zeitschriftentitel:
Molecular Systems Biology
Jahr:
2023
Band / Volume:
20
Heft / Issue:
1
Seitenangaben Beitrag:
28-55
Volltext / DOI:
doi:10.1038/s44320-023-00004-7
Verlag / Institution:
Springer Science and Business Media LLC
E-ISSN:
1744-4292
Publikationsdatum:
18.12.2023
 BibTeX