Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea.

Heiser, Clemens; Steffen, Armin; Strollo, Patrick J; Giaie-Miniet, Claire; Vanderveken, Olivier M; Hofauer, Benedikt

doi:10.1007/s11325-022-02663-6

2023

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Titel:: Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea.
Dokumenttyp:: Journal Article
Autor(en):: Heiser, Clemens; Steffen, Armin; Strollo, Patrick J; Giaie-Miniet, Claire; Vanderveken, Olivier M; Hofauer, Benedikt
Abstract:: PURPOSE: Hypoglossal nerve stimulation (HNS) has been shown to treat obstructive sleep apnea (OSA) effectively. The aim of this study was to compare HNS with positive airway pressure (PAP) treatment regarding outcome parameters: (1) sleepiness, (2) apnea-hypopnea index (AHI), and (3) effectiveness. METHODS: Propensity score matching with nearest neighbor algorithm was used to compare outcomes of HNS and PAP therapy in a real-world setting. Data were collected at baseline and 12 months after initiating OSA treatment including demographics, Epworth Sleepiness Scale (ESS), AHI, and objective adherence data. To account for overall treatment efficacy, the mean disease alleviation (MDA) was calculated. RESULTS: Of 227 patients who received treatment consecutively, 126 could be matched 1:1 with regard to age, body mass index, and AHI. After matching, no statistically significant differences between the groups were found. A clinically important symptom improvement was seen at 12 months in both cohorts, though there was a greater difference in ESS improvement in patients treated with HNS (8.0 ± 5.1 points vs. 3.9 ± 6.8 points; p = 0.042). In both groups, mean posttreatment AHI was significantly reduced (HNS: 8.1 ± 6.3/h; PAP: 6.6 ± 8.0/h; p < 0.001). Adherence after 12 months among patients treated with HNS was higher than in those receiving PAP therapy (5.0 ± 2.6 h/night; 4.0 ± 2.1 h/night) but not with statistical significance. Overall effectiveness calculated with the MDA was 59% in patients treated with HNS compared to 51% receiving PAP. CONCLUSION: Patients treated with HNS therapy had significantly greater improvements in daytime sleepiness compared to PAP therapy, while the mean reduction of AHI and overall effectiveness were comparable for both treatments. TRIAL REGISTRATION: ClinicalTrial.gov Identifier: NCT03756805.
Zeitschriftentitel:: Sleep Breath
Jahr:: 2023
Band / Volume:: 27
Heft / Issue:: 2
Seitenangaben Beitrag:: 693-701
Volltext / DOI:: doi:10.1007/s11325-022-02663-6
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/35779166
Print-ISSN:: 1520-9512
TUM Einrichtung:: Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (Prof. Wollenberg)2023